AG Jünemann/Schönburg - Heart&Brain

Mitarbeiter*innen

Prof. Dr. med. Tibo Gerriets; Dr. rer. nat. Marius Butz, Dipl.-Psych; Rolf Meyer, M. Sc.-Psych; Jasmin El-Shazly, M. Sc.-Psych; Prof. Dr. med. Patrick Schramm; Prof. Dr. med. Marlene Tschernatsch-Gerriets

 

Schwerpunkte der Arbeitsgruppe

Laufende Projekte

• INCORE - INcreasing preoperative COgnitive REserve to prevent postoperative delirium and postoperative cognitive decline in cardiac surgical patients. A randomized controlled trial on cognitive training (NCT04493996)
• COSTA - Cognitive Outcome after Surgical and Transcatheter Aortic valve replacement (NCT04535076)
• DESTRESS-SURG - DEcreasing preoperative STRESS to prevent postoperative delirium and postoperative cognitive decline in cardiac SURGical patients. A randomized controlled trial on relaxation interventions via virtual reality and binaural beats (NCT05036538)
• BICAPONI - Analysis of blood BIomarkers in CArdiac surgery patients with POstoperative Neurocognitive disorders and sub-clinical brain Infarcts (DRKS00031711)
• CAVALIR - ProspeCtive Analysis of preoperative heart rate VAriability and psychophysiological stress parameters as biomarkers for postoperative deLIRium and neurocognitive disorders in cardiac surgery patients (DRKS00035318)

Geplante Projekte

• RECOG - Prevention of Seizures after Cardiac Surgery to REduce Postoperative COGnitive Deficits (RCT)
• CONCISE - COrrelation between postoperative Neurocognition and perioperative subclinical Cerebral ISchemia in cardiac surgery patiEnts (DRKS00033944)

 

Drittmittel

Abgeschlossen

MEDEX 2	111.823 €		William G. Kerckhoff-Stiftung
Tako-Tsubo	60.000 €		Deutsche Stiftung für Herzforschung (DSHF)
COFAS	20.000 €		UKGM
ELMAR	108.000 €		Else Kröner-Fresenius-Stiftung (EKFS)
NEOCARE	75.600 €		Willy und Monika Pitzer-Stiftung
INCOGNITO	36.000 €		William G. Kerckhoff-Stiftung +
	30.300 €		Deutsche Stiftung für Herzforschung (DSHF)
COFAS 1000	5.000 €		William G. Kerckhoff-Stiftung

 

Laufend

INCORE	seit 2019	5.084 €		William G. Kerckhoff-Stiftung
COSTA	seit 2020	58.265 €		Deutsche Stiftung für Herzforschung (DSHF)
DESTRESS	seit 2022	65.106 €		Deutsche Stiftung für Herzforschung (DSHF)
BICAPONI	seit 2023	43.324 €		William G. Kerckhoff-Stiftung

 

Kollaborationen

Prof. Dr. Georg Bachmann, Prof. Dr. Stefan Blankenberg, Prof. Dr. Andreas Böning, PD Dr. Tobias Braun, Prof. Dr. Yeong-Hoon Choi, Prof. Dr. Thorsten Döppner, PD Dr. Stefan Gerner, Prof. Dr. Bettina Hamann, Dr. Samra Hamzic, Prof. Dr. Jürgen Hennig, Prof. Dr. Till Keller, PD Dr. Won-Keun Kim, PD Dr. Philip Klemm, Prof. Dr. Thomas Mengden, Prof. Dr. phil. Gebhard Sammer, Dr. Johanna Wagner-Dörr, Dipl.-Psych., Dr. Mesut Yenigün

Publikationen (Auswahl)

• Butz M, Gerriets T, Sammer G, El-Shazly J, Braun T, Sünner L, Meyer R, Tschernatsch M, Schramm P, Gerner ST, Doeppner TR, Mengden T, Choi YH, Schoenburg M, Juenemann M. The impact of white matter lesions and subclinical cerebral ischemia on postoperative cognitive training outcomes after heart valve surgery: A randomized clinical trial. J Neurol Sci. 2025 Feb 15;469:123370. doi: 10.1016/j.jns.2024.123370. Epub 2024 Dec 26. PMID: 39764915.
• Meyer R, Huhn R, Schramm P, Gerriets T, Schoenburg M, Juenemann M, Butz M. Machbarkeit einer präoperativen Entspannungsintervention bei kardiochirurgischen Patienten via virtueller Realität und binauralen Beats zur Vermeidung von postoperativen neurokognitiven Störungen. Neurol Rehabil 2024; 30(S3): S1–S76; doi.org/10.14624/NR24S30.
• Butz M, El-Shazly J, Gerriets T, Meyer R, Tschernatsch M, Braun T, Schramm P, Doeppner TR, Gerner ST, Boening A, Choi YH, Schoenburg M, Juenemann M. Patient-Reported Postoperative Neuropsychological Deterioration After Heart Valve Replacement and Coronary Artery Bypass Grafting. CJC Open. 2024 Apr 15;6(4):615-623. doi: 10.1016/j.cjco.2023.11.007. PMID: 38708044; PMCID: PMC11065655.
• Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Braun T, Meyer R, Schramm P, Doeppner TR, Böning A, Mengden T, Choi YH, Schönburg M, Juenemann M. Twelve-month follow-up effects of cognitive training after heart valve surgery on cognitive functions and health-related quality of life: a randomised clinical trial. Open Heart. 2023 Nov 27;10(2):e002411. doi: 10.1136/openhrt-2023-002411. PMID: 38011994; PMCID: PMC10685926.
• Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Schramm P, Doeppner TR, Braun T, Boening A, Mengden T, Choi YH, Schoenburg M, Juenemann M. The impact of postoperative cognitive training on health-related quality of life and cognitive failures in daily living after heart valve surgery: A randomized clinical trial. Brain Behav. 2023 Mar;13(3):e2915. doi: 10.1002/brb3.2915. Epub 2023 Feb 13. PMID: 36785920; PMCID: PMC10013943.
• Butz M, Meyer R, Gerriets T, Sammer G, Doerr JM, El-Shazly J, Doeppner TR, Choi YH, Schoenburg M, Juenemann M. Increasing preoperative cognitive reserve to prevent postoperative delirium and postoperative cognitive decline in cardiac surgical patients (INCORE): Study protocol for a randomized clinical trial on cognitive training. Front Neurol. 2022 Dec 12;13:1040733. doi: 10.3389/fneur.2022.1040733. PMID: 36578306; PMCID: PMC9791586.
• Tschernatsch M, El Shazly J, Butz M, Lie SR, Yeniguen M, Braun T, Bachmann G, Schoenburg M, Gerriets T, Schramm P, Juenemann M. Visual Hallucinations following Coronary Artery Bypass Grafting: A Prospective Study. Medicina (Kaunas). 2022 Oct 16;58(10):1466. doi: 10.3390/medicina58101466. PMID: 36295626; PMCID: PMC9610531.
• Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Huttner HB, Braun T, Boening A, Mengden T, Choi YH, Schoenburg M, Juenemann M. Effects of postoperative cognitive training on neurocognitive decline after heart surgery: A randomized clinical trial. Eur J Cardiothorac Surg. 2022 Apr 12:ezac251. doi: 10.1093/ejcts/ezac251. Epub ahead of print. PMID: 35415742.
• El Shazly J, Gerriets T, Hennig J, Butz M, Kastaun S, Wiedenroth CB, Schoenburg M, Wollenschlaeger M, Bachmann G, Guth S, Juenemann M. Neuroprotective effects of dynamic bubble trap use in patients undergoing pulmonary endarterectomy: a two-arm randomized controlled trial. J Thorac Dis. 2021 Oct;13(10):5807-5817. doi: 10.21037/jtd-21-831. PMID: 34795929; PMCID: PMC8575830.
• Hamzic S, Braun T, Butz M, Khilan H, Weber S, Yeniguen M, Gerriets T, Schramm P, Juenemann M. Transesophageal Echocardiography - Dysphagia Risk in Acute Stroke (TEDRAS): a prospective, blind, randomized and controlled clinical trial. Eur J Neurol. 2021 Jan;28(1):172-181. doi: 10.1111/ene.14516. Epub 2020 Oct 10. PMID: 32897605.
• Tschernatsch M, Juenemann M, Alhaidar F, El Shazly J, Butz M, Meyer M, Gerriets T, Schönburg M, Schramm P. Epileptic seizure discharges in patients after open chamber cardiac surgery-a prospective prevalence pilot study using continuous electroencephalography. Intensive Care Med. 2020 Jul;46(7):1418-1424. doi: 10.1007/s00134-020-06073-8. Epub 2020 May 13. PMID: 32405742; PMCID: PMC7334279.
• Juenemann M, Nef H, Möllmann H, Singh P, Troidl C, Schramm P, Kaps M, Gerriets T, Blaes F, Tschernatsch M. No evidence for humoral autoimmunity against cardiomyocytes, adrenergic or muscarinic receptors in patients with Tako-Tsubo cardiomyopathy. Immunobiology. 2019 Mar;224(2):220-222. doi: 10.1016/j.imbio.2018.11.005. Epub 2018 Nov 15. PMID: 30554740.
• Kastaun S, Gerriets T, Tschernatsch M, Yeniguen M, Juenemann M. Psychosocial and psychoneuroendocrinal aspects of Takotsubo syndrome. Nat Rev Cardiol. 2016 Nov;13(11):688-694. doi: 10.1038/nrcardio.2016.108. Epub 2016 Jul 14. PMID: 27411402.
• Kastaun S, Gerriets T, Schwarz NP, Yeniguen M, Schoenburg M, Tanislav C, Juenemann M. The Relevance of Postoperative Cognitive Decline in Daily Living: Results of a 1-Year Follow-up. J Cardiothorac Vasc Anesth. 2016 Apr;30(2):297-303. doi: 10.1053/j.jvca.2015.12.008. Epub 2015 Dec 3. PMID: 27013120.
• Kastaun S, Gerriets T, Yeniguen M, Nef H, Moellmann H, Sammer G, Juenemann M. Locus of control and stress management strategies in women with takotsubo cardiomyopathy. Int J Cardiol. 2014 Dec 15;177(2):658-60. doi: 10.1016/j.ijcard.2014.09.173. Epub 2014 Oct 5. PMID: 25308089.
• Kastaun S, Schwarz NP, Juenemann M, Yeniguen M, Nef HM, Moellmann H, Hamm CW, Sammer G, Hennig J, Bachmann G, Gerriets T. Cortisol awakening and stress response, personality and psychiatric profiles in patients with takotsubo cardiomyopathy. Heart. 2014 Nov;100(22):1786-92. doi: 10.1136/heartjnl-2014-305745. Epub 2014 Jul 1. PMID: 24986894.

• Gerriets T, Schwarz N, Sammer G, Baehr J, Stolz E, Kaps M, Kloev Ersetzenekorn WP, Bachmann G, Schönburg M. Protecting the brain from gaseous and solid micro-emboli during coronary artery bypass grafting: a randomized controlled trial. Eur Heart J. 2010 Feb;31(3):360-8. doi: 10.1093/eurheartj/ehp178. Epub 2009 Jun 18. PMID: 19541675

 

Abgeschlossene Bachelorarbeiten

• Selina Rührgartner-Beranek, B.Sc. (Psychologie): Präoperatives kognitives Training vor kardiochirurgischen Eingriffen: Effekte des Trainings und der Einfluss von Angst und Depression auf kognitive Leistungsfähigkeit (2024, in Kooperation mit Prof. Dr. Lepach-Engelhardt, Private Fachhochschule Göttingen)
• Hannah Schmidt, B.Sc. (Biologie): Association between preoperative neuropsychology and acute subclinical cerebral ischemia after on-pump cardiac surgery (a retrospective analysis) (2024, in Kooperation mit Dipl.-Ing. Holger Christ, Hochschule Fresenius, University of Applied Sciences)
• Viktoria T.S. Hoffmann, B.Sc. (Psychologie): Der Einfluss postoperativer akuter ischämischer Mikroläsionen auf die neuropsychologische Leistung nach randomisiert kontrolliertem kognitiven Training bei herzchirurgischen Patienten (2021, in Kooperation mit Prof. Dr. Claus Vögele, Universität Luxemburg)

 

Abgeschlossene Promotionsarbeiten

• Marius Butz, Dr. rer. nat. Dipl.-Psych.: Effekte eines postoperativen kognitiven Trainings auf postoperative kognitive Defizite nach herzchirurgischen Operationen (2023, in Kooperation mit Prof. Dr. Gebhard Sammer, Justus-Liebig-Universität Gießen)